Reaction Details
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50465327
Substrate
n/a
Meas. Tech.
ChEMBL_1784569 (CHEMBL4256086)
IC50
0.022±n/a nM
Citation
Cui, Z; Wang, X; Koppermann, S; Thorson, JS; Ducho, C; Van Lanen, SG Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471. J Nat Prod 81:942-948 (2018) [PubMed] Article More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_STAAU | mraY
Type:
PROTEIN
Mol. Mass.:
35238.55
Organism:
Staphylococcus aureus (strain MRSA252)
Description:
ChEMBL_827497
Residue:
321
Sequence:
MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIVITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAIIFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATGLSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFATISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKVVTVFWAVGLISGLIGLWIGVH
Inhibitor
Name:
BDBM50465327
Synonyms:
CHEMBL4279378
Type:
Small organic molecule
Emp. Form.:
C52H89N11O18
Mol. Mass.:
1156.326
SMILES:
[H][C@](O[C@@H]1O[C@H](CN)[C@@H](O)[C@H]1OC)([C@H](NCCCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)N[C@@H](C(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1)[C@@H](OC(=O)CCCCCCCCCCC(C)C)C(C)C)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Structure:
