Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM50025124
Substrate
n/a
Meas. Tech.
ChEMBL_84708 (CHEMBL694447)
Ki
1.2±n/a nM
Citation
 Wouters, W; Janssen, CG; Van Dun, J; Thijssen, JB; Laduron, PM In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. J Med Chem 29:1663-8 (1986) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
  
Inhibitor
Name:
BDBM50025124
Synonyms:
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-7-hydroxy-1H-quinazoline-2,4-dione | CHEMBL46683
Type:
Small organic molecule
Emp. Form.:
C22H22FN3O4
Mol. Mass.:
411.4262
SMILES:
Oc1ccc2c(c1)[nH]c(=O)n(CCN1CCC(CC1)C(=O)c1ccc(F)cc1)c2=O
Structure:
Search PDB for entries with ligand similarity: