Reaction Details
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Potassium voltage-gated channel subfamily KQT member 4
Ligand
BDBM50465775
Substrate
n/a
Meas. Tech.
ChEMBL_1788748 (CHEMBL4260482)
EC50
1600±n/a nM
Citation
Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y Novel K Bioorg Med Chem Lett 28:3793-3797 (2018) [PubMed] Article More Info.:
Target
Name:
Potassium voltage-gated channel subfamily KQT member 4
Synonyms:
KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4
Type:
PROTEIN
Mol. Mass.:
77131.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1520985
Residue:
695
Sequence:
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
Inhibitor
Name:
BDBM50465775
Synonyms:
CHEMBL1703636
Type:
Small organic molecule
Emp. Form.:
C17H23NO
Mol. Mass.:
257.3706
SMILES:
Cc1cc(C)c(NC(=O)C2CC3CCC2C3)c(C)c1 |TLB:7:9:15:13.12|
Structure:
