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Target
Targeting protein for Xklp2
Ligand
BDBM50315769
Substrate
n/a
Meas. Tech.
ChEMBL_1794205 (CHEMBL4266322)
Ki
490±n/a nM
Citation
 Borisa, AC; Bhatt, HG A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies. Eur J Med Chem 140:1-19 (2017) [PubMed]  Article 
Target
Name:
Targeting protein for Xklp2
Synonyms:
C20orf1 | C20orf2 | DIL-2 | DIL2 | Differentially expressed in cancerous and non-cancerous lung cells 2 | HCA519 | Hepatocellular carcinoma-associated antigen 519 | Hepatocellular carcinoma-associated antigen 90 | Protein fls353 | Restricted expression proliferation-associated protein 100 | TPX2 | TPX2_HUMAN | Targeting protein for Xklp2 | p100
Type:
PROTEIN
Mol. Mass.:
85686.81
Organism:
Homo sapiens
Description:
ChEMBL_117017
Residue:
747
Sequence:
MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPKFSTRFHC
  
Inhibitor
Name:
BDBM50315769
Synonyms:
3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea | 4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]-pyridine | CHEMBL1090479 | GSK-1070916
Type:
Small organic molecule
Emp. Form.:
C30H33N7O
Mol. Mass.:
507.6293
SMILES:
CCn1cc(c(n1)-c1ccc(NC(=O)N(C)C)cc1)-c1ccnc2[nH]c(cc12)-c1cccc(CN(C)C)c1
Structure:
Search PDB for entries with ligand similarity: