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Target
Adenosine receptor A1
Ligand
BDBM50025718
Substrate
n/a
Meas. Tech.
ChEBML_28519
IC50
1200±n/a nM
Citation
 Hamilton, HW; Ortwine, DF; Worth, DF; Bristol, JA Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists. J Med Chem 30:91-6 (1987) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50025718
Synonyms:
1,3-Dimethyl-5-(3-nitro-phenyl)-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one | CHEMBL176743
Type:
Small organic molecule
Emp. Form.:
C13H11N5O3
Mol. Mass.:
285.2581
SMILES:
Cc1nn(C)c2c1nc([nH]c2=O)-c1cccc(c1)[N+]([O-])=O
Structure:
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