Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50467317
Substrate
n/a
Meas. Tech.
ChEMBL_1795781 (CHEMBL4267898)
Ki
107±n/a nM
Citation
 Rui, M; Rossino, G; Coniglio, S; Monteleone, S; Scuteri, A; Malacrida, A; Rossi, D; Catenacci, L; Sorrenti, M; Paolillo, M; Curti, D; Venturini, L; Schepmann, D; Wünsch, B; Liedl, KR; Cavaletti, G; Pace, V; Urban, E; Collina, S Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents. Eur J Med Chem 158:353-370 (2018) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50467317
Synonyms:
CHEMBL4286416
Type:
Small organic molecule
Emp. Form.:
C27H32ClNO2
Mol. Mass.:
438.001
SMILES:
Cl.COc1ccc2cc(ccc2c1)C(=O)CCCN1CCC(Cc2ccccc2)CC1
Structure:
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