Reaction Details Report a problem with these data
Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM50027176
Substrate
n/a
Meas. Tech.
ChEMBL_1796184 (CHEMBL4268301)
IC50
85600±n/a nM
Citation
 Ch?o?-Rzepa, G; ?lusarczyk, M; Jankowska, A; Gawalska, A; Bucki, A; Ko?aczkowski, M; ?wierczek, A; Pociecha, K; Wyska, E; Zygmunt, M; Kazek, G; Sa?at, K; Paw?owski, M Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain. Eur J Med Chem 158:517-533 (2018) [PubMed]  Article 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM50027176
Synonyms:
2-Acetoxy-Benzoic Acid | 3-Isobutyl-Methylxanthine | CHEBI:34795 | ISOBUTYLMETHYLXANTHINE
Type:
Small organic molecule
Emp. Form.:
C10H14N4O2
Mol. Mass.:
222.2438
SMILES:
CC(C)Cn1c2[nH]cnc2c(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity: