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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50467705
Substrate
n/a
Meas. Tech.
ChEMBL_1796653 (CHEMBL4268770)
Ki
60±n/a nM
Citation
 Eng, WS; Rejman, D; Pohl, R; West, NP; Woods, K; Naesens, LMJ; Keough, DT; Guddat, LW Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. Eur J Med Chem 159:10-22 (2018) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
2.4.2.8 | HGPRT | HGPRT_MYCTU | HGPRTase | Hypoxanthine-guanine phosphoribosyltransferase | hprT | hprT | hpt
Type:
PROTEIN
Mol. Mass.:
22244.35
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_117829
Residue:
202
Sequence:
MHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ
  
Inhibitor
Name:
BDBM50467705
Synonyms:
CHEMBL4282830
Type:
Small organic molecule
Emp. Form.:
C14H21N5O10P2
Mol. Mass.:
481.2916
SMILES:
O[C@H](CO[C@@H]1CN(C[C@H]1n1cnc2c(O)ncnc12)C(=O)CCP(O)(O)=O)P(O)(O)=O |r|
Structure:
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