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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50467707
Substrate
n/a
Meas. Tech.
ChEMBL_1796653 (CHEMBL4268770)
Ki
40±n/a nM
Citation
 Eng, WS; Rejman, D; Pohl, R; West, NP; Woods, K; Naesens, LMJ; Keough, DT; Guddat, LW Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. Eur J Med Chem 159:10-22 (2018) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
2.4.2.8 | HGPRT | HGPRT_MYCTU | HGPRTase | Hypoxanthine-guanine phosphoribosyltransferase | hprT | hprT | hpt
Type:
PROTEIN
Mol. Mass.:
22244.35
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_117829
Residue:
202
Sequence:
MHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ
  
Inhibitor
Name:
BDBM50467707
Synonyms:
CHEMBL4280490
Type:
Small organic molecule
Emp. Form.:
C14H22N6O9P2
Mol. Mass.:
480.3068
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1OCCP(O)(O)=O)C(=O)CCP(O)(O)=O |r|
Structure:
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