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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50467708
Substrate
n/a
Meas. Tech.
ChEMBL_1796660 (CHEMBL4268777)
Ki
8.0±n/a nM
Citation
 Eng, WS; Rejman, D; Pohl, R; West, NP; Woods, K; Naesens, LMJ; Keough, DT; Guddat, LW Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. Eur J Med Chem 159:10-22 (2018) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50467708
Synonyms:
CHEMBL4277753
Type:
Small organic molecule
Emp. Form.:
C14H22N6O10P2
Mol. Mass.:
496.3062
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@H]1OC[C@H](O)P(O)(O)=O)C(=O)CCP(O)(O)=O |r|
Structure:
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