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Target
Chaperone SurA
Ligand
BDBM50467856
Substrate
n/a
Meas. Tech.
ChEMBL_1797153 (CHEMBL4269270)
IC50
56980±n/a nM
Citation
 Bell, EW; Zheng, EJ; Ryno, LM Identification of inhibitors of the E. coli chaperone SurA using in silico and in vitro techniques. Bioorg Med Chem Lett 28:3540-3548 (2018) [PubMed]  Article 
Target
Name:
Chaperone SurA
Synonyms:
5.2.1.8 | Chaperone SurA | PPIase SurA | Peptidyl-prolyl cis-trans isomerase SurA | Rotamase SurA | SURA_ECOLI | Survival protein A | surA
Type:
PROTEIN
Mol. Mass.:
47285.20
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_117815
Residue:
428
Sequence:
MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAAQARQQLPDDATLRHQIMERLIMDQIILQMGQKMGVKISDEQLDQAIANIAKQNNMTLDQMRSRLAYDGLNYNTYRNQIRKEMIISEVRNNEVRRRITILPQEVESLAQQVGNQNDASTELNLSHILIPLPENPTSDQVNEAESQARAIVDQARNGADFGKLAIAHSADQQALNGGQMGWGRIQELPGIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGESKNISVTEVHARHILLKPSPIMTDEQARVKLEQIAADIKSGKTTFAAAAKEFSQDPGSANQGGDLGWATPDIFDPAFRDALTRLNKGQMSAPVHSSFGWHLIELLDTRNVDKTDAAQKDRAYRMLMNRKFSEEAASWMQEQRASAYVKILSN
  
Inhibitor
Name:
BDBM50467856
Synonyms:
CHEMBL4285388
Type:
Small organic molecule
Emp. Form.:
C27H22N2O4
Mol. Mass.:
438.4746
SMILES:
OC(=O)[C@@H](Cc1ccc2ccccc2n1)NC(=O)OCC1c2ccccc2-c2ccccc12 |r|
Structure:
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