Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50467994
Substrate
n/a
Meas. Tech.
ChEMBL_1797534 (CHEMBL4269651)
Ki
860±n/a nM
Citation
 Meleddu, R; Distinto, S; Cottiglia, F; Angius, R; Gaspari, M; Taverna, D; Melis, C; Angeli, A; Bianco, G; Deplano, S; Fois, B; Del Prete, S; Capasso, C; Alcaro, S; Ortuso, F; Yanez, M; Supuran, CT; Maccioni, E Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides. ACS Med Chem Lett 9:1045-1050 (2018) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50467994
Synonyms:
CHEMBL4279217
Type:
Small organic molecule
Emp. Form.:
C19H15N3O2S3
Mol. Mass.:
413.536
SMILES:
NS(=O)(=O)c1ccc(cc1)\N=c1/scc(-c2cccs2)n1-c1ccccc1
Structure:
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