Reaction Details
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Guanine nucleotide-binding protein G(o) subunit alpha
Ligand
BDBM50468903
Substrate
n/a
Meas. Tech.
ChEMBL_1801543 (CHEMBL4273835)
IC50
>100000±n/a nM
Citation
Zhang, H; Nielsen, AL; Boesgaard, MW; Harpsøe, K; Daly, NL; Xiong, XF; Underwood, CR; Haugaard-Kedström, LM; Bräuner-Osborne, H; Gloriam, DE; Strømgaard, K Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. Eur J Med Chem 156:847-860 (2018) [PubMed] Article More Info.:
Target
Name:
Guanine nucleotide-binding protein G(o) subunit alpha
Synonyms:
GNAO_RAT | Gna0 | Gnao | Gnao1 | Guanine nucleotide-binding protein G(o) subunit alpha
Type:
PROTEIN
Mol. Mass.:
40061.56
Organism:
Rattus norvegicus
Description:
ChEMBL_118030
Residue:
354
Sequence:
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKADSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
Inhibitor
Name:
BDBM50468903
Synonyms:
CHEMBL4279374
Type:
Small organic molecule
Emp. Form.:
C43H73N7O16
Mol. Mass.:
944.077
SMILES:
CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](CO)N(C)C(=O)[C@@H](CC(C)C)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r|
Structure:
