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Target
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Ligand
BDBM50468900
Substrate
n/a
Meas. Tech.
ChEMBL_1801542 (CHEMBL4273834)
IC50
>100000±n/a nM
Citation
 Zhang, H; Nielsen, AL; Boesgaard, MW; Harpsøe, K; Daly, NL; Xiong, XF; Underwood, CR; Haugaard-Kedström, LM; Bräuner-Osborne, H; Gloriam, DE; Strømgaard, K Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. Eur J Med Chem 156:847-860 (2018) [PubMed]  Article 
Target
Name:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Synonyms:
Adenylate cyclase-stimulating G alpha protein | Extra large alphas protein | GNAS | GNAS1 | GNAS1_HUMAN | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | XLalphas
Type:
PROTEIN
Mol. Mass.:
110988.45
Organism:
Homo sapiens
Description:
ChEMBL_118094
Residue:
1037
Sequence:
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
  
Inhibitor
Name:
BDBM50468900
Synonyms:
CHEMBL4282827
Type:
Small organic molecule
Emp. Form.:
C45H67N7O15
Mol. Mass.:
946.0514
SMILES:
CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@H](COC1=O)NC(C)=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r|
Structure:
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