Reaction Details Report a problem with these data
Target
Signal peptidase I
Ligand
BDBM50469170
Substrate
n/a
Meas. Tech.
ChEMBL_1803498 (CHEMBL4275790)
IC50
42±n/a nM
Citation
Sza?aj, N; Lu, L; Benediktsdottir, A; Zamaratski, E; Cao, S; Olanders, G; Hedgecock, C; Karlén, A; Erdélyi, M; Hughes, D; Mowbray, SL; Brandt, P Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase. Eur J Med Chem 157:1346-1360 (2018) [PubMed] Article
More Info.:
Target
Name:
Signal peptidase I
Synonyms:
LEP_ECOLI | Leader peptidase I | SPase I | lepB
Type:
PROTEIN
Mol. Mass.:
35961.43
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_154169
Residue:
324
Sequence:
MANMFALILVIATLVTGILWCVDKFFFAPKRRERQAAAQAAAGDSLDKATLKKVAPKPGWLETGASVFPVLAIVLIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCSSGQACENALPVTYSNVEPSDFVQTFSRRNGGEATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDKQEGEWPTGLRLSRIGGIH