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Target
mRNA cap guanine-N7 methyltransferase
Ligand
BDBM50470536
Substrate
n/a
Meas. Tech.
ChEMBL_1803088 (CHEMBL4275380)
IC50
1383±n/a nM
Citation
 Niroula, D; Hallada, LP; Le Chapelain, C; Ganegamage, SK; Dotson, D; Rogelj, S; Groll, M; Tello-Aburto, R Design, synthesis, and evaluation of cystargolide-based ?-lactones as potent proteasome inhibitors. Eur J Med Chem 157:962-977 (2018) [PubMed]  Article 
Target
Name:
mRNA cap guanine-N7 methyltransferase
Synonyms:
2.1.1.56 | KIAA0398 | MCES_HUMAN | RG7MT1 | RNMT | hCMT1 | hMet | hcm1p | mRNA (guanine-N(7)-)-methyltransferase | mRNA cap guanine-N7 methyltransferase | mRNA cap methyltransferase
Type:
PROTEIN
Mol. Mass.:
54843.48
Organism:
Homo sapiens
Description:
ChEMBL_117907
Residue:
476
Sequence:
MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLSEKTSVCRQVDIARKRKEFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRETEDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVGLEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATSIYLVFAFEKQQ
  
Inhibitor
Name:
BDBM50470536
Synonyms:
CHEMBL4292798
Type:
Small organic molecule
Emp. Form.:
C25H37N3O5
Mol. Mass.:
459.5784
SMILES:
[H][C@]1([C@@H](C)CC)[C@@H](OC1=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: