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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50470099
Substrate
n/a
Meas. Tech.
ChEMBL_100131 (CHEMBL858015)
Ki
0.018±n/a nM
Citation
 Haviv, F; Fitzpatrick, TD; Nichols, CJ; Bush, EN; Diaz, G; Bammert, G; Nguyen, AT; Johnson, ES; Knittle, J; Greer, J In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem 37:701-5 (1994) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50470099
Synonyms:
CHEMBL2371295
Type:
Small organic molecule
Emp. Form.:
C60H76ClFN12O10
Mol. Mass.:
1179.771
SMILES:
CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1ccc(F)cc1 |wU:55.60,12.20,wD:43.54,31.41,23.28,5.4,61.64,(27.36,-6,;27.38,-7.53,;26.06,-8.31,;24.72,-7.54,;23.42,-8.31,;24.69,-6.05,;25.9,-5.16,;25.38,-3.71,;23.85,-3.73,;23.43,-5.16,;22.1,-5.92,;22.08,-7.44,;20.76,-5.16,;20.78,-3.61,;22.11,-2.84,;22.14,-1.32,;23.47,-.56,;23.49,.99,;24.82,1.74,;22.15,1.76,;19.44,-5.9,;18.11,-5.13,;18.12,-3.58,;16.77,-5.89,;16.76,-7.43,;18.09,-8.22,;19.41,-7.44,;18.06,-9.75,;15.44,-5.12,;14.1,-5.87,;14.1,-7.4,;12.78,-5.09,;12.88,-3.57,;13.64,-2.23,;12.85,-.9,;13.59,.45,;15.15,.47,;15.9,1.82,;15.94,-.87,;15.19,-2.2,;11.46,-5.86,;10.11,-5.06,;10.11,-3.54,;8.78,-5.83,;8.78,-7.37,;10.1,-8.15,;10.08,-9.7,;11.42,-10.47,;12.75,-9.72,;14.07,-10.47,;12.77,-8.17,;11.43,-7.38,;7.46,-5.05,;6.12,-5.8,;6.11,-7.35,;4.8,-5.03,;4.8,-3.51,;6.12,-2.75,;3.45,-5.79,;2.13,-5.02,;2.16,-3.49,;.78,-5.77,;.78,-7.31,;2.1,-8.09,;3.52,-7.47,;4.55,-8.62,;3.76,-9.95,;4.23,-11.42,;3.2,-12.55,;1.68,-12.23,;1.22,-10.76,;2.26,-9.63,;-.54,-5,;-1.87,-5.76,;-1.79,-7.27,;-3.25,-5.08,;-4.65,-6.09,;-6.21,-5.38,;-7.61,-6.4,;-9.17,-5.71,;-9.35,-4,;-10.9,-3.22,;-7.97,-2.97,;-6.39,-3.68,)|
Structure:
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