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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50470101
Substrate
n/a
Meas. Tech.
ChEMBL_100131 (CHEMBL858015)
Ki
0.026±n/a nM
Citation
 Haviv, F; Fitzpatrick, TD; Nichols, CJ; Bush, EN; Diaz, G; Bammert, G; Nguyen, AT; Johnson, ES; Knittle, J; Greer, J In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem 37:701-5 (1994) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50470101
Synonyms:
CHEMBL406887
Type:
Small organic molecule
Emp. Form.:
C64H85FN14O11
Mol. Mass.:
1245.4453
SMILES:
CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCNC(=O)c1cccnc1)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1cccc(F)c1 |wU:61.66,12.20,wD:23.28,31.46,5.4,67.70,48.50,(28.94,-13.15,;28.96,-14.67,;27.64,-15.47,;26.3,-14.7,;25,-15.47,;26.27,-13.19,;27.48,-12.31,;26.95,-10.87,;25.43,-10.87,;25.01,-12.32,;23.68,-13.06,;23.66,-14.61,;22.34,-12.31,;22.36,-10.76,;23.69,-10,;23.71,-8.45,;25.04,-7.7,;25.07,-6.16,;26.4,-5.39,;23.72,-5.38,;21.02,-13.06,;19.69,-12.29,;19.7,-10.74,;18.34,-13.03,;18.33,-14.57,;19.66,-15.37,;20.99,-14.6,;19.63,-16.89,;17.01,-12.25,;15.67,-13.02,;15.67,-14.54,;14.35,-12.24,;14.44,-10.71,;13.22,-9.74,;13.74,-8.29,;12.38,-7.26,;13.05,-5.87,;12.19,-4.58,;12.86,-3.19,;10.61,-4.71,;9.77,-3.43,;8.19,-3.55,;7.55,-4.93,;8.44,-6.22,;9.97,-6.09,;13.02,-13,;11.67,-12.22,;11.67,-10.68,;10.34,-12.98,;10.32,-14.51,;11.64,-15.3,;11.64,-16.85,;12.98,-17.62,;14.32,-16.86,;15.64,-17.63,;14.34,-15.31,;13,-14.54,;9.02,-12.19,;9.03,-10.64,;7.68,-12.95,;7.67,-14.51,;6.36,-12.18,;6.36,-10.64,;7.7,-9.89,;5,-12.93,;3.68,-12.16,;3.71,-10.63,;2.33,-12.92,;2.33,-14.47,;3.65,-15.25,;5.07,-14.63,;6.1,-15.77,;5.32,-17.11,;5.78,-18.57,;4.75,-19.7,;3.23,-19.37,;2.77,-17.91,;3.81,-16.79,;1.01,-12.16,;-.32,-12.9,;-.29,-14.43,;-1.7,-12.19,;-3.11,-13.15,;-4.66,-12.38,;-4.79,-10.64,;-6.31,-9.9,;-7.75,-10.87,;-7.63,-12.6,;-9.12,-13.5,;-6.08,-13.35,)|
Structure:
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