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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50470132
Substrate
n/a
Meas. Tech.
ChEMBL_100131 (CHEMBL858015)
Ki
0.025±n/a nM
Citation
 Haviv, F; Fitzpatrick, TD; Nichols, CJ; Bush, EN; Diaz, G; Bammert, G; Nguyen, AT; Johnson, ES; Knittle, J; Greer, J In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem 37:701-5 (1994) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50470132
Synonyms:
CHEMBL2370208
Type:
Small organic molecule
Emp. Form.:
C67H85N15O12
Mol. Mass.:
1292.4851
SMILES:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1 |wU:88.94,63.67,31.32,45.48,23.24,wD:5.4,77.83,57.61,12.13,(36.44,8.14,;34.94,7.83,;34.46,6.38,;32.95,6.07,;31.92,7.22,;32.47,4.61,;33.37,3.36,;32.44,2.11,;30.99,2.61,;30.99,4.14,;29.68,4.91,;29.62,6.47,;28.37,4.08,;28.43,2.53,;29.81,1.83,;29.87,.29,;31.25,-.44,;31.32,-1.99,;32.69,-2.69,;30.02,-2.82,;26.99,4.81,;25.69,3.97,;25.76,2.41,;24.33,4.68,;24.25,6.23,;25.54,7.06,;26.92,6.35,;25.48,8.6,;23.01,3.84,;21.63,4.56,;21.57,6.12,;20.32,3.73,;20.41,2.18,;21.76,1.47,;23.3,1.54,;23.85,.09,;22.66,-.87,;22.56,-2.4,;21.21,-3.08,;19.9,-2.25,;20,-.71,;21.38,-.02,;18.96,4.45,;17.66,3.62,;17.72,2.06,;16.28,4.33,;16.22,5.86,;17.52,6.71,;18.9,5.99,;20.19,6.83,;20.13,8.36,;21.44,9.2,;18.75,9.08,;17.43,8.25,;14.97,3.49,;13.59,4.21,;13.52,5.75,;12.3,3.37,;12.37,1.83,;13.74,1.12,;10.92,4.1,;9.61,3.27,;9.68,1.71,;8.23,3.97,;8.17,5.51,;7.08,6.61,;5.53,6.54,;4.97,7.98,;6.17,8.95,;6.25,10.48,;7.62,11.19,;8.91,10.35,;8.83,8.81,;7.47,8.11,;6.94,3.14,;5.56,3.84,;5.48,5.38,;4.26,3.01,;4.32,1.47,;5.7,.77,;6.98,1.6,;8.35,.9,;8.43,-.64,;7.13,-1.48,;5.77,-.77,;2.88,3.73,;1.57,2.89,;1.63,1.34,;.22,3.62,;.21,5.16,;-1.26,5.62,;-2.16,4.37,;-3.7,4.36,;-1.25,3.14,)|
Structure:
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