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Target
Dihydrofolate reductase
Ligand
BDBM50471880
Substrate
n/a
Meas. Tech.
ChEMBL_55074 (CHEMBL858762)
Ki
10000±n/a nM
Citation
 Selassie, CD; Gan, WX; Kallander, LS; Klein, TE Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase. J Med Chem 41:4261-72 (1998) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_LACCA | dhfR | folA
Type:
PROTEIN
Mol. Mass.:
18437.08
Organism:
Lactobacillus casei
Description:
ChEMBL_1357878
Residue:
163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
  
Inhibitor
Name:
BDBM50471880
Synonyms:
CHEMBL342714
Type:
Small organic molecule
Emp. Form.:
C12H14N4O
Mol. Mass.:
230.2658
SMILES:
COc1ccccc1Cc1cnc(N)nc1N
Structure:
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