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Target
Phosphoglycerate kinase 1
Ligand
BDBM50472923
Substrate
n/a
Meas. Tech.
ChEMBL_152781 (CHEMBL765582)
IC50
100000±n/a nM
Citation
 Bressi, JC; Choe, J; Hough, MT; Buckner, FS; Van Voorhis, WC; Verlinde, CL; Hol, WG; Gelb, MH Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. J Med Chem 43:4135-50 (2000) [PubMed]  Article 
Target
Name:
Phosphoglycerate kinase 1
Synonyms:
Cell migration-inducing gene 10 protein | PGK1 | PGK1_HUMAN | PGKA | PGKA | PRP 2 | Phosphoglycerate kinase 1 | Primer recognition protein 2
Type:
PROTEIN
Mol. Mass.:
44619.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104832
Residue:
417
Sequence:
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
  
Inhibitor
Name:
BDBM50472923
Synonyms:
CHEMBL608967
Type:
Small organic molecule
Emp. Form.:
C26H30N6O5
Mol. Mass.:
506.5536
SMILES:
OC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(NCCc3ccc(O)cc3)nc(NCCc3ccccc3)nc12 |r|
Structure:
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