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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50044623
Substrate
n/a
Meas. Tech.
ChEMBL_322064 (CHEMBL871772)
Ki
13±n/a nM
Citation
 Ahmed, M; Briggs, MA; Bromidge, SM; Buck, T; Campbell, L; Deeks, NJ; Garner, A; Gordon, L; Hamprecht, DW; Holland, V; Johnson, CN; Medhurst, AD; Mitchell, DJ; Moss, SF; Powles, J; Seal, JT; Stean, TO; Stemp, G; Thompson, M; Trail, B; Upton, N; Winborn, K; Witty, DR Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists. Bioorg Med Chem Lett 15:4867-71 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_RAT | Htr6 | ST-B17 | Serotonin (5-HT) receptor | Serotonin 6 (5-HT6) receptor | Serotonin receptor 6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46945.51
Organism:
RAT
Description:
5-HT6 HTR6 RAT::P31388
Residue:
436
Sequence:
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
  
Inhibitor
Name:
BDBM50044623
Synonyms:
CHEMBL193400
Type:
Small organic molecule
Emp. Form.:
C18H17Cl2N3O2S
Mol. Mass.:
410.317
SMILES:
Clc1cccc(c1)S(=O)(=O)n1ccc2c(N3CCNCC3)c(Cl)ccc12
Structure:
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