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Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM50475599
Substrate
n/a
Meas. Tech.
ChEMBL_328940 (CHEMBL859890)
IC50
20500±n/a nM
Citation
 Antane, S; Caufield, CE; Hu, W; Keeney, D; Labthavikul, P; Morris, K; Naughton, SM; Petersen, PJ; Rasmussen, BA; Singh, G; Yang, Y Pulvinones as bacterial cell wall biosynthesis inhibitors. Bioorg Med Chem Lett 16:176-80 (2006) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
MURD_STAAU | MurD (S. aureus) | murD
Type:
Protein
Mol. Mass.:
49837.61
Organism:
Staphylococcus aureus (Firmicutes)
Description:
S. aureus MurD
Residue:
449
Sequence:
MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVVSGSHPLTLLDNNPIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYKPHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIESEELKAKTLYFSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAIIDSLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIWLCGGLDRGNEFDELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVLLSPACASWDQYSTFEERGEKFIERFRAHLPSY
  
Inhibitor
Name:
BDBM50475599
Synonyms:
CHEMBL200097
Type:
Small organic molecule
Emp. Form.:
C25H18Cl2O3
Mol. Mass.:
437.315
SMILES:
Cc1ccccc1-c1ccc(\C=C2/OC(O)=C(C2=O)c2cc(Cl)cc(Cl)c2)cc1C |c:16|
Structure:
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