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Target
Tryptase delta
Ligand
BDBM50475862
Substrate
n/a
Meas. Tech.
ChEMBL_386990 (CHEMBL862961)
Ki
7000±n/a nM
Citation
 Yu, W; Dener, JM; Dickman, DA; Grothaus, P; Ling, Y; Liu, L; Havel, C; Malesky, K; Mahajan, T; O'Brian, C; Shelton, EJ; Sperandio, D; Tong, Z; Yee, R; Mordenti, JJ Identification of metabolites of the tryptase inhibitor CRA-9249: observation of a metabolite derived from an unexpected hydroxylation pathway. Bioorg Med Chem Lett 16:4053-8 (2006) [PubMed]  Article 
Target
Name:
Tryptase delta
Synonyms:
Delta-tryptase | HmMCP-3-like tryptase III | Mast cell mMCP-7-like | TPSD1 | TRYD_HUMAN | Tryptase delta | Tryptase-3
Type:
PROTEIN
Mol. Mass.:
26578.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104777
Residue:
242
Sequence:
MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGPYWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPYPLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVNGT
  
Inhibitor
Name:
BDBM50475862
Synonyms:
CHEMBL379076
Type:
Small organic molecule
Emp. Form.:
C19H15F4N5O2
Mol. Mass.:
421.3483
SMILES:
Cn1c(nc2ccc(cc12)C(=O)NCCO)C(F)(F)c1nc2c(F)cc(F)cc2[nH]1
Structure:
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