Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50476046
Substrate
n/a
Meas. Tech.
ChEMBL_422811 (CHEMBL856530)
IC50
3980±n/a nM
Citation
 Zuse, A; Schmidt, P; Baasner, S; Böhm, KJ; Müller, K; Gerlach, M; Günther, EG; Unger, E; Prinz, H 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem 49:7816-25 (2006) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50476046
Synonyms:
CHEMBL218921
Type:
Small organic molecule
Emp. Form.:
C21H18O3S
Mol. Mass.:
350.431
SMILES:
COc1ccc(COc2c3ccsc3cc3ccccc23)cc1OC
Structure:
Search PDB for entries with ligand similarity: