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Target
Potassium voltage-gated channel subfamily B member 2
Ligand
BDBM50375645
Substrate
n/a
Meas. Tech.
ChEMBL_423344 (CHEMBL855454)
IC50
18100±n/a nM
Citation
 Liu, H; Gao, ZB; Yao, Z; Zheng, S; Li, Y; Zhu, W; Tan, X; Luo, X; Shen, J; Chen, K; Hu, GY; Jiang, H Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay. J Med Chem 50:83-93 (2007) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily B member 2
Synonyms:
KCNB2 | KCNB2_HUMAN | Voltage-gated potassium channel subunit Kv2.2
Type:
PROTEIN
Mol. Mass.:
102555.84
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105708
Residue:
911
Sequence:
MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM
  
Inhibitor
Name:
BDBM50375645
Synonyms:
CHEMBL219301 | US11542290, Compound A-3
Type:
Small organic molecule
Emp. Form.:
C12H13ClN2O2S
Mol. Mass.:
284.762
SMILES:
NCCNS(=O)(=O)c1cccc2c(Cl)cccc12
Structure:
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