Reaction Details Report a problem with these data
Target
Transporter
Ligand
BDBM50017666
Substrate
n/a
Meas. Tech.
ChEBML_129897
IC50
4700±n/a nM
Citation
 Högberg, T; Ulff, B; Renyi, AL; Ross, SB Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake. J Med Chem 24:1499-507 (1982) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters
Type:
PROTEIN
Mol. Mass.:
66787.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1463061
Residue:
597
Sequence:
MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
  
Inhibitor
Name:
BDBM50017666
Synonyms:
1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane | 2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine | 3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine | 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine | 3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine | BROMPHENIRAMINE | CHEMBL811
Type:
Small organic molecule
Emp. Form.:
C16H19BrN2
Mol. Mass.:
319.239
SMILES:
CN(C)CCC(c1ccc(Br)cc1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: