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Target
Integrase
Ligand
BDBM50477769
Substrate
n/a
Meas. Tech.
ChEMBL_458636 (CHEMBL941965)
IC50
18000±n/a nM
Citation
 Al-Mawsawi, LQ; Dayam, R; Taheri, L; Witvrouw, M; Debyser, Z; Neamati, N Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors. Bioorg Med Chem Lett 17:6472-5 (2007) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50477769
Synonyms:
CHEMBL398970
Type:
Small organic molecule
Emp. Form.:
C25H23N5O4S
Mol. Mass.:
489.546
SMILES:
COc1ccc(cc1)-n1c(Cc2ccccc2)nnc1SCC(=O)NNC(=O)c1ccccc1O
Structure:
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