Reaction Details Report a problem with these data
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50074960
Substrate
n/a
Meas. Tech.
ChEMBL_478367 (CHEMBL931319)
Ki
110±n/a nM
Citation
 Barb, AW; Jiang, L; Raetz, CR; Zhou, P Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proc Natl Acad Sci U S A 104:18433-8 (2007) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
3.5.1.108 | UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-N-acetylglucosamine deacetylase | lpxC
Type:
PROTEIN
Mol. Mass.:
34415.56
Organism:
Rhizobium leguminosarum bv. trifolii (strain WSM1325)
Description:
ChEMBL_118424
Residue:
318
Sequence:
MAIGLLGFQTTVSRPVTLSGTGVHSGAEVSITLNPAESDTGVVFQRLHDNGDITELKAVSSQVGNTDLCTVLGFSPAHSVATIEHVMAAVYALGLDNVVIEVQGSEMPIMDGSSLPFVEAIEQVGLVSLGVKRRYIRITKPVRIEHGGSWSEFRPYDGTRFEVEIDFECPLIGRQKWAGDMTPAVFKAELSRARTFGFMRDVERLWASGHALGSSLENSVVISDDNTVINVEGLRYAKDEFVRHKTLDAVGDLSLAGVQFIGCYRSYRGGHKMNANALKALLADSSAYEVVETSTPRQRVAARELIAVSASEFAPWSA
  
Inhibitor
Name:
BDBM50074960
Synonyms:
(R)-2-(3,4-Dimethoxy-5-propyl-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid hydroxyamide | (R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide | CHEMBL107313 | L-161240
Type:
Small organic molecule
Emp. Form.:
C15H20N2O5
Mol. Mass.:
308.3297
SMILES:
CCCc1cc(cc(OC)c1OC)C1=N[C@H](CO1)C(=O)NO |t:14|
Structure:
Search PDB for entries with ligand similarity: