Reaction Details Report a problem with these data
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50478376
Substrate
n/a
Meas. Tech.
ChEMBL_478367 (CHEMBL931319)
Ki
0.700000±n/a nM
Citation
 Barb, AW; Jiang, L; Raetz, CR; Zhou, P Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proc Natl Acad Sci U S A 104:18433-8 (2007) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
3.5.1.108 | UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-N-acetylglucosamine deacetylase | lpxC
Type:
PROTEIN
Mol. Mass.:
34415.56
Organism:
Rhizobium leguminosarum bv. trifolii (strain WSM1325)
Description:
ChEMBL_118424
Residue:
318
Sequence:
MAIGLLGFQTTVSRPVTLSGTGVHSGAEVSITLNPAESDTGVVFQRLHDNGDITELKAVSSQVGNTDLCTVLGFSPAHSVATIEHVMAAVYALGLDNVVIEVQGSEMPIMDGSSLPFVEAIEQVGLVSLGVKRRYIRITKPVRIEHGGSWSEFRPYDGTRFEVEIDFECPLIGRQKWAGDMTPAVFKAELSRARTFGFMRDVERLWASGHALGSSLENSVVISDDNTVINVEGLRYAKDEFVRHKTLDAVGDLSLAGVQFIGCYRSYRGGHKMNANALKALLADSSAYEVVETSTPRQRVAARELIAVSASEFAPWSA
  
Inhibitor
Name:
BDBM50478376
Synonyms:
BB-78485 | CHEMBL261713
Type:
Small organic molecule
Emp. Form.:
C23H20N2O4S
Mol. Mass.:
420.481
SMILES:
ONC(=O)[C@@H](Cc1ccc2ccccc2c1)NS(=O)(=O)c1ccc2ccccc2c1 |r|
Structure:
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