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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50478609
Substrate
n/a
Meas. Tech.
ChEMBL_532089 (CHEMBL993302)
IC50
64.7±n/a nM
Citation
 Dembitsky, VM Bioactive peroxides as potential therapeutic agents. Eur J Med Chem 43:223-51 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50478609
Synonyms:
Hydroperoxycadiforin
Type:
Small organic molecule
Emp. Form.:
C50H76O6
Mol. Mass.:
773.1348
SMILES:
[H][C@]12[#6]-[#6]-[#6](-[#6][C@]3([#6]\[#6]=[#6](\[#6])-[#6])[#6](=O)[C@]4([#6]\[#6]=[#6](\[#6])-[#6])[#6]-[#6@H](-[#6]\[#6]=[#6](\[#6])-[#6])[C@@]([#6])([#6]-[#6]\[#6]=[#6](\[#6])-[#6])[C@]([#6](=O)-[#6](-[#6])-[#6])([#6]3=O)[#6]4=O)=[#6][C@]1([H])[#6@H](-[#6]-[#6][C@@]2([#6])[#8]-[#8])-[#6](-[#6])-[#6] |r,c:46,THB:44:43:6.41.12:20.21.27|
Structure:
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