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Target
Tubulin beta chain
Ligand
BDBM50478798
Substrate
n/a
Meas. Tech.
ChEMBL_530359 (CHEMBL968455)
IC50
>20000±n/a nM
Citation
 Odlo, K; Hentzen, J; dit Chabert, JF; Ducki, S; Gani, OA; Sylte, I; Skrede, M; Flørenes, VA; Hansen, TV 1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin. Bioorg Med Chem 16:4829-38 (2008) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50478798
Synonyms:
CHEMBL477479
Type:
Small organic molecule
Emp. Form.:
C18H18N4O6
Mol. Mass.:
386.3587
SMILES:
COc1ccc(cc1[N+]([O-])=O)-c1cnnn1-c1cc(OC)c(OC)c(OC)c1
Structure:
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