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Target
Chymotrypsin-like elastase family member 1/2A
Ligand
BDBM50479191
Substrate
n/a
Meas. Tech.
ChEMBL_510667 (CHEMBL1005628)
IC50
>67000±n/a nM
Citation
 Taori, K; Paul, VJ; Luesch, H Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp. J Nat Prod 71:1625-9 (2008) [PubMed]  Article 
Target
Name:
Chymotrypsin-like elastase family member 1/2A
Synonyms:
Pancreatic elastase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 152345
Components:
This complex has 2 components.
Component 1
Name:
Chymotrypsin-like elastase family member 1
Synonyms:
CELA1 | CELA1_PIG | ELA1 | Elastase | Elastase 1 | Elastase-1 | Pancreatic elastase
Type:
Enzyme
Mol. Mass.:
28827.71
Organism:
Sus scrofa (Pig)
Description:
P00772
Residue:
266
Sequence:
MLRLLVVASLVLYGHSTQDFPETNARVVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWVMTAAHCVDRELTFRVVVGEHNLNQNDGTEQYVGVQKIVVHPYWNTDDVAAGYDIALLRLAQSVTLNSYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQLAQTLQQAYLPTVDYAICSSSSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQYAVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN
  
Component 2
Name:
Chymotrypsin-like elastase family member 2A
Synonyms:
CEL2A_PIG | CELA2A | ELA2 | ELA2A | Elastase 2A | Elastase-2 | Elastase-2A | Pancreatic elastase
Type:
PROTEIN
Mol. Mass.:
28705.23
Organism:
Sus scrofa
Description:
ChEMBL_156951
Residue:
269
Sequence:
MIRALLLSTLVAGALSCGLPANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGGTLVDQSWVLTAAHCISSSRTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGNDIALLKLASPVSLTDKIQLGCLPAAGTILPNNYVCYVTGWGRLQTNGASPDILQQGQLLVVDYATCSKPGWWGSTVKTNMICAGGDGIISSCNGDSGGPLNCQGANGQWQVHGIVSFGSSLGCNYYHKPSVFTRVSNYIDWINSVIANN
  
Inhibitor
Name:
BDBM50479191
Synonyms:
KEMPOPEPTIN B
Type:
Small organic molecule
Emp. Form.:
C46H73BrN8O11
Mol. Mass.:
994.023
SMILES:
[H][C@]12CC[C@@H](O)N(C1=O)[C@@]([H])([C@@H](C)CC)C(=O)N(C)[C@@H](Cc1ccc(OC)c(Br)c1)C(=O)N[C@@H](C(C)C)C(=O)O[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)CCC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N2 |r|
Structure:
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