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Target
Peptidoglycan D,D-transpeptidase MrdA
Ligand
BDBM50350470
Substrate
n/a
Meas. Tech.
ChEMBL_553672 (CHEMBL960465)
IC50
16600±n/a nM
Citation
 Davies, TA; Page, MG; Shang, W; Andrew, T; Kania, M; Bush, K Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother 51:2621-4 (2007) [PubMed]  Article 
Target
Name:
Peptidoglycan D,D-transpeptidase MrdA
Synonyms:
3.4.16.4 | AO964_03845 | AOY09_05445 | C0046_27725 | C8257_05325 | CAZ03_33860 | CAZ10_26315 | CGU42_07245 | CRX60_00455 | DC19_04850 | DI492_29940 | DN070_10950 | DZ934_12725 | DZ940_19030 | DZ962_23955 | E4V10_04960 | EQH76_28325 | IPC3_29275 | IPC669_09400 | NCTC13719_00971 | PAERUG_E15_London_28_01_14_04647 | PBP-2 | Penicillin-binding protein 2 | Peptidoglycan D,D-transpeptidase MrdA | RW109_RW109_01676 | pbpA | spoVD
Type:
PROTEIN
Mol. Mass.:
72223.59
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_105732
Residue:
646
Sequence:
MPQPIHLKDHEKDARLVRRRVIVGAVAVVLLTLVLVARMYHLQVTQYEYHSTLSENNRVHVQPIPPTRGIIFDRNGVIIADNRPSFSLTITRERTEDLQKTLDTLVEILGLTEDDRAIFEKRMKQGRRPFEPVPIMFELNEEQIARIAVNQFRLPGVDVATQFVRHYPLKEHFAHSVGYVGRINEQELKNLDPINYSGTHHIGKTGIERFYESELHGTVGYEEVETNARGRVLRVLKRTDPIPGKDIVLSIDSRLQEAAENALAGRRGAIVAIQPSTGDVLAMVSQPSYDPNLFVTGISFKAYAELRDSIDRPLYNRVLRGLYPPGSTVKPAVALAGLDAGVVTPTSRVFDPGYYQLPNYDHKYRNWNRYGDGWVSLESAIYRSNDTYFYDLAHKLGIDRLHAFMSRFGFGQKVALDMFGEADGLMPSREWKRKTRRQVWYPGETLILGIGQGYMQATPIQLAQMTALLANKGHWIRPHLAKTIDGQPPVDPDPMPDIVLRDPANWDRVDYGMQQVVHGARGTARKVGATSAYLIAGKSGTAQVVAIKQNERYDRSKLLERHRDHALFVGFAPANNPQIAVAVMVENGESGSGVAAPVVKQVMDAWLLDEHGKLKAEYAEPVAPLAAAVAKPEPTAAEPEAPALEQ
  
Inhibitor
Name:
BDBM50350470
Synonyms:
CEFEPIME | Maxipime
Type:
Small organic molecule
Emp. Form.:
C19H24N6O5S2
Mol. Mass.:
480.561
SMILES:
CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[N+]3(C)CCCC3)=C(N2C1=O)C([O-])=O)c1csc(N)n1 |r,c:19|
Structure:
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