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Target
Peptidoglycan D,D-transpeptidase FtsI
Ligand
BDBM50240480
Substrate
n/a
Meas. Tech.
ChEMBL_553819 (CHEMBL966182)
IC50
68.9±n/a nM
Citation
 Davies, TA; Page, MG; Shang, W; Andrew, T; Kania, M; Bush, K Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother 51:2621-4 (2007) [PubMed]  Article 
Target
Name:
Peptidoglycan D,D-transpeptidase FtsI
Synonyms:
3.4.16.4 | AO964_07895 | CAZ03_05815 | CAZ10_21230 | CGU42_01090 | CRX60_22815 | CW299_32685 | DC19_24320 | DI492_11155 | DN070_30405 | DZ934_06595 | DZ940_08385 | DZ962_00565 | E4V10_06485 | EFK68_01815 | HQ52_24085 | IPC3_13380 | IPC669_10550 | NCTC13719_04773 | PAERUG_E15_London_28_01_14_00534 | PBP-3 | Penicillin-binding protein 3 | Peptidoglycan D,D-transpeptidase FtsI | RW109_RW109_05757 | ftsI_1 | ftsI_2 | pbpB
Type:
PROTEIN
Mol. Mass.:
62874.12
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_105732
Residue:
579
Sequence:
MKLNYFQGALYPWRFCVIVGLLLAMVGAIVWRIVDLHVIDHDFLKGQGDARSVRHIAIPAHRGLITDRNGEPLAVSTPVTTLWANPKELMTAKERWPQLAAALGQDTKLFADRIEQNAEREFIYLVRGLTPEQGEGVIALKVPGVYSIEEFRRFYPAGEVVAHAVGFTDVDDRGREGIELAFDEWLAGVPGKRQVLKDRRGRVIKDVQVTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIMDVKTGEILAMTNQPTYNPNNRRNLQPAAMRNRAMIDVFEPGSTVKPFSMSAALASGRWKPSDIVDVYPGTLQIGRYTIRDVSRNSRQLDLTGILIKSSNVGISKIAFDIGAESIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYGYGLSVTAIQLAHAYAALANDGKSVPLSMTRVDRVPDGVQVISPEVASTVQGMLQQVVEAQGGVFRAQVPGYHAAGKSGTARKVSVGTKGYRENAYRSLFAGFAPATDPRIAMVVVIDEPSKAGYFGGLVSAPVFSKVMAGALRLMNVPPDNLPTATEQQQVNAAPAKGGRG
  
Inhibitor
Name:
BDBM50240480
Synonyms:
(2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate | (2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate(aztreonam) | 2-[1-(2-Amino-thiazol-4-yl)-1-((2S,3S)-2-methyl-4-oxo-1-sulfo-azetidin-3-ylcarbamoyl)-meth-(Z)-ylideneaminooxy]-2-methyl-propionic acid | AZTREONAM | Azactam | Azetreonam | CHEMBL158 | SQ-26776
Type:
Small organic molecule
Emp. Form.:
C13H17N5O8S2
Mol. Mass.:
435.433
SMILES:
C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\c2csc(N)n2)C(=O)N1S(O)(=O)=O |r|
Structure:
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