Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM97233
Substrate
n/a
Meas. Tech.
ChEMBL_495611 (CHEMBL1000303)
IC50
760±n/a nM
Citation
 Prinz, H; Schmidt, P; Böhm, KJ; Baasner, S; Müller, K; Unger, E; Gerlach, M; Günther, EG 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem 52:1284-94 (2009) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM97233
Synonyms:
CHEMBL9514 | MLS001164242 | N-[6-(2-thenoyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester | N-[6-[oxo(thiophen-2-yl)methyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester | Nocodazole | SMR000326904 | cid_4122 | methyl N-(6-thiophen-2-ylcarbonyl-1H-benzimidazol-2-yl)carbamate | methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate | methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
Type:
Small organic molecule
Emp. Form.:
C14H11N3O3S
Mol. Mass.:
301.32
SMILES:
COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1cccs1
Structure:
Search PDB for entries with ligand similarity: