Reaction Details Report a problem with these data
Target
Signal peptidase I
Ligand
BDBM50480585
Substrate
n/a
Meas. Tech.
ChEMBL_576754 (CHEMBL1032021)
IC50
180±n/a nM
Citation
 Harris, DA; Powers, ME; Romesberg, FE Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase. Bioorg Med Chem Lett 19:3787-90 (2009) [PubMed]  Article 
Target
Name:
Signal peptidase I
Synonyms:
LEP_ECOLI | Leader peptidase I | SPase I | lepB
Type:
PROTEIN
Mol. Mass.:
35961.43
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_154169
Residue:
324
Sequence:
MANMFALILVIATLVTGILWCVDKFFFAPKRRERQAAAQAAAGDSLDKATLKKVAPKPGWLETGASVFPVLAIVLIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCSSGQACENALPVTYSNVEPSDFVQTFSRRNGGEATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDKQEGEWPTGLRLSRIGGIH
  
Inhibitor
Name:
BDBM50480585
Synonyms:
CHEMBL555725
Type:
Small organic molecule
Emp. Form.:
C8H9NO4S
Mol. Mass.:
215.226
SMILES:
[H][C@@]12SC=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O |r,c:3|
Structure:
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