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Target
Isocitrate lyase
Ligand
BDBM50478639
Substrate
n/a
Meas. Tech.
ChEMBL_587468 (CHEMBL1042189)
IC50
67700±n/a nM
Citation
 Song, J; Jeong, W; Wang, N; Lee, HS; Sim, CJ; Oh, KB; Shin, J Scalarane sesterterpenes from the sponge Smenospongia sp. J Nat Prod 71:1866-71 (2008) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_MAGO7 | ICL | ICL1 | Isocitrase | Isocitratase
Type:
PROTEIN
Mol. Mass.:
61002.51
Organism:
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae)
Description:
ChEMBL_438441
Residue:
547
Sequence:
MASKNMVNPAVEPSMEDDLFAREVAEVKQWWSDPRWRYTKRPFTAEQIVSKRGNLKIEYPSNAQSKKLWKILEGRFQKRDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASSSDEPGPDLADYPYTTVPNKVSHLFMAQLFHDRKQRHERLSAPKSERSKLQNIDYLRPIIADADTGHGGLTAVMKLTKLFIEKGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGVDLLAIARTDAEAATLITTSIDPRDHAFILGCTNPSLQPLADLMNTAEQSGKTGDQLQAIEDEWMAKANLKRFDDAVVDVINSSSSIRNPKDVAAKYLQAAKGKSNREARAIASSLGVPEIFFDWDSPRTREGYFRIKGGCDCAINRAIAYAPYADAIWMESKLPDYEQAKEFAEGVHAVYPEQKLAYNLSPSFNWKTAMPRDEQETYIRRLAGLGYCWQFITLAGLHTTALISDRFARAYSEVGMRAYGELVQEPEMELGVDVVKHQKWSGATYVDELQKMVTGGVSSTAAMGKGVTEDQFH
  
Inhibitor
Name:
BDBM50478639
Synonyms:
(7E,12E,18R,20Z)-Variabilin | CHEMBL467744
Type:
Small organic molecule
Emp. Form.:
C25H34O4
Mol. Mass.:
398.5351
SMILES:
C[C@H](CCC\C(C)=C\CC\C(C)=C\CCc1ccoc1)\C=C1/OC(=O)C(C)=C1O |r,c:27|
Structure:
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