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Target
Mannose-6-phosphate isomerase
Ligand
BDBM50481224
Substrate
n/a
Meas. Tech.
ChEMBL_604867 (CHEMBL1065976)
Ki
10500±n/a nM
Citation
 Foret, J; de Courcy, B; Gresh, N; Piquemal, JP; Salmon, L Synthesis and evaluation of non-hydrolyzable D-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-D-mannose as a new strong inhibitor of phosphomannose isomerases. Bioorg Med Chem 17:7100-7 (2009) [PubMed]  Article 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
5.3.1.8 | MPI_YEAST | Mannose-6-phosphate isomerase | PMI | PMI40 | Phosphohexomutase | Phosphomannose isomerase
Type:
PROTEIN
Mol. Mass.:
48183.62
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_109240
Residue:
429
Sequence:
MSNKLFRLDAGYQQYDWGKIGSSSAVAQFAAHSDPSVQIEQDKPYAELWMGTHSKMPSYNHESKESLRDIISKNPSAMLGKDIIDKFHATNELPFLFKVLSIEKVLSIQAHPDKALGKILHAQDPKNYPDDNHKPEMAIAVTDFEGFCGFKPLQEIADELKRIPELRNIVGEETSRNFIENIQPSAQKGSPEDEQNKKLLQAVFSRVMNASDDKIKIQARSLVERSKNSPSDFNKPDLPELIQRLNKQFPDDVGLFCGCLLLNHCRLNAGEAIFLRAKDPHAYISGDIMECMAASDNVVRAGFTPKFKDVKNLVSMLTYTYDPVEKQKMQPLKFDRSSGNGKSVLYNPPIEEFAVLETTFDEKLGQRHFEGVDGPSILITTKGNGYIKADGQKLKAEPGFVFFIAPHLPVDLEAEDEAFTTYRAFVEPN
  
Inhibitor
Name:
BDBM50481224
Synonyms:
CHEMBL611642
Type:
Small organic molecule
Emp. Form.:
C9H14O9
Mol. Mass.:
266.2021
SMILES:
OC1O[C@H](CC(C(O)=O)C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O |r|
Structure:
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