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Target
Voltage-dependent L-type calcium channel subunit beta-1
Ligand
BDBM50481493
Substrate
n/a
Meas. Tech.
ChEMBL_610290 (CHEMBL1068015)
IC50
100±n/a nM
Citation
 Pajouhesh, H; Feng, ZP; Ding, Y; Zhang, L; Pajouhesh, H; Morrison, JL; Belardetti, F; Tringham, E; Simonson, E; Vanderah, TW; Porreca, F; Zamponi, GW; Mitscher, LA; Snutch, TP Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorg Med Chem Lett 20:1378-83 (2010) [PubMed]  Article 
Target
Name:
Voltage-dependent L-type calcium channel subunit beta-1
Synonyms:
CAB1 | CACB1_HUMAN | CACNB1 | CACNLB1 | Calcium channel voltage-dependent subunit beta 1 | Voltage-dependent L-type calcium channel subunit beta-1
Type:
PROTEIN
Mol. Mass.:
65714.34
Organism:
Homo sapiens
Description:
ChEMBL_117730
Residue:
598
Sequence:
MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYPSSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGTPPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR
  
Inhibitor
Name:
BDBM50481493
Synonyms:
CHEMBL597783
Type:
Small organic molecule
Emp. Form.:
C32H38FN3O
Mol. Mass.:
499.662
SMILES:
CN1CCC(CC1)C(N1CCN(CC1)C(=O)CC(c1ccccc1)c1ccccc1)c1ccc(F)cc1
Structure:
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