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Target
Retinol-binding protein 4
Ligand
BDBM50501921
Substrate
n/a
Meas. Tech.
ChEMBL_1805921 (CHEMBL4305280)
IC50
2.7±n/a nM
Citation
 Cioffi, CL; Racz, B; Varadi, A; Freeman, EE; Conlon, MP; Chen, P; Zhu, L; Kitchen, DB; Barnes, KD; Martin, WH; Pearson, PG; Johnson, G; Blaner, WS; Petrukhin, K Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis. J Med Chem 62:5470-5500 (2019) [PubMed]  Article 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM50501921
Synonyms:
CHEMBL4462481
Type:
Small organic molecule
Emp. Form.:
C20H19F3N4O
Mol. Mass.:
388.3863
SMILES:
Cc1ccc2nc(cn2n1)C(=O)N1CCC(CC1)c1ccccc1C(F)(F)F
Structure:
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