Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 10
Ligand
BDBM50482296
Substrate
n/a
Meas. Tech.
ChEMBL_640600 (CHEMBL1175513)
IC50
>100000±n/a nM
Citation
 Kim, EJ; Ryu, HW; Curtis-Long, MJ; Han, J; Kim, JY; Cho, JK; Kang, D; Park, KH Chemoselective regulation of TREK2 channel: activation by sulfonate chalcones and inhibition by sulfonamide chalcones. Bioorg Med Chem Lett 20:4237-9 (2010) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 10
Synonyms:
KCNKA_RAT | Kcnk10 | Outward rectifying potassium channel protein TREK-2 | Potassium channel subfamily K member 10 | TREK-2 K(+) channel subunit | Trek2
Type:
PROTEIN
Mol. Mass.:
59814.68
Organism:
Rattus norvegicus
Description:
ChEMBL_109237
Residue:
538
Sequence:
MKFPIETPRKQVNWDPKVAVPAAAPPVCQPKSATNGHHPVPRLSISSRATVVARMEGASQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETLIQHALDADNAGVSPVGNSSNSSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSKLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEDETEKMCNSDNSSTAMLTECIQQQAEMENGMVPMDTKDQGLENNSLLEDRN
  
Inhibitor
Name:
BDBM50482296
Synonyms:
CHEMBL1169729
Type:
Small organic molecule
Emp. Form.:
C22H19NO3S
Mol. Mass.:
377.456
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccccc1
Structure:
Search PDB for entries with ligand similarity: