Reaction Details Report a problem with these data
Target
Eukaryotic peptide chain release factor GTP-binding subunit
Ligand
BDBM50482421
Substrate
n/a
Meas. Tech.
ChEMBL_647706 (CHEMBL1220303)
EC50
100000±n/a nM
Citation
 Feng, BY; Toyama, BH; Wille, H; Colby, DW; Collins, SR; May, BC; Prusiner, SB; Weissman, J; Shoichet, BK Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol 4:197-9 (2008) [PubMed]  Article 
Target
Name:
Eukaryotic peptide chain release factor GTP-binding subunit
Synonyms:
ERF-3 | ERF2 | ERF3 | ERF3_YEAST | G1 to S phase transition protein 1 | GST1 | Omnipotent suppressor protein 2 | PNM2 | PSI no more protein 2 | Polypeptide release factor 3 | SAL3 | SUF12 | SUP2 | SUP35 | Translation release factor 3
Type:
Protein
Mol. Mass.:
76553.53
Organism:
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Description:
P05453
Residue:
685
Sequence:
MSDSNQGNNQQNYQQYSQNGNQQQGNNRYQGYQAYNAQAQPAGGYYQNYQGYSGYQQGGYQQYNPDAGYQQQYNPQGGYQQYNPQGGYQQQFNPQGGRGNYKNFNYNNNLQGYQAGFQPQSQGMSLNDFQKQQKQAAPKPKKTLKLVSSSGIKLANATKKVGTKPAESDKKEEEKSAETKEPTKEPTKVEEPVKKEEKPVQTEEKTEEKSELPKVEDLKISESTHNTNNANVTSADALIKEQEEEVDDEVVNDMFGGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMDTNKEERNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGASQADVGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERYDQCVSNVSNFLRAIGYNIKTDVVFMPVSGYSGANLKDHVDPKECPWYTGPTLLEYLDTMNHVDRHINAPFMLPIAAKMKDLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQNIYNETENEVDMAMCGEQVKLRIKGVEEEDISPGFVLTSPKNPIKSVTKFVAQIAIVELKSIIAAGFSCVMHVHTAIEEVHIVKLLHKLEKGTNRKSKKPPAFAKKGMKVIAVLETEAPVCVETYQDYPQLGRFTLRDQGTTIAIGKIVKIAE
  
Inhibitor
Name:
BDBM50482421
Synonyms:
TERAIODOPHENOLPHATHALIN
Type:
Small organic molecule
Emp. Form.:
C20H10I4O4
Mol. Mass.:
821.9089
SMILES:
[#8]-[#6](=O)-c1ccccc1\[#6](-[#6]-1-[#6]=[#6](I)-[#6](=O)-[#6](I)=[#6]-1)=[#6]-1\[#6]=[#6](I)-[#6](=O)-[#6](I)=[#6]-1 |c:18,28,t:12,22|
Structure:
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