Reaction Details Report a problem with these data
Target
Chaperone protein PapD
Ligand
BDBM50482441
Substrate
n/a
Meas. Tech.
ChEMBL_646951 (CHEMBL1217092)
IC50
22000±n/a nM
Citation
 Chorell, E; Pinkner, JS; Phan, G; Edvinsson, S; Buelens, F; Remaut, H; Waksman, G; Hultgren, SJ; Almqvist, F Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. J Med Chem 53:5690-5 (2010) [PubMed]  Article 
Target
Name:
Chaperone protein PapD
Synonyms:
Chaperone protein PapD | PAPD_ECOLX | papD
Type:
PROTEIN
Mol. Mass.:
26807.50
Organism:
Escherichia coli
Description:
ChEMBL_109176
Residue:
239
Sequence:
MIRKKILMAAIPLFVISGADAAVSLDRTRAVFDGSEKSMTLDISNDNKQLPYLAQAWIENENQEKIITGPVIATPPVQRLEPGAKSMVRLSTTPDISKLPQDRESLFYFNLREIPPRSEKANVLQIALQTKIKLFYRPAAIKTRPNEVWQDQLILNKVSGGYRIENPTPYYVTVIGLGGSEKQAEEGEFETVMLSPRSEQTVKSANYNTPYLSYINDYGGRPVLSFICNGSRCSVKKEK
  
Inhibitor
Name:
BDBM50482441
Synonyms:
CHEMBL1213947
Type:
Small organic molecule
Emp. Form.:
C29H25NO3S
Mol. Mass.:
467.579
SMILES:
COC(=O)[C@@H]1C(Sc2c(C3CC3)c(Cc3cccc4ccccc34)cc(=O)n12)c1ccccc1 |r|
Structure:
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