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Target
G-protein coupled receptor Mth
Ligand
BDBM50482586
Substrate
n/a
Meas. Tech.
ChEMBL_653054 (CHEMBL1226257)
Kd
326±n/a nM
Citation
 Ja, WW; West, AP; Delker, SL; Bjorkman, PJ; Benzer, S; Roberts, RW Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor. Nat Chem Biol 3:415-9 (2007) [PubMed]  Article 
Target
Name:
G-protein coupled receptor Mth
Synonyms:
MTH_DROME | Protein methuselah | mth
Type:
PROTEIN
Mol. Mass.:
59647.78
Organism:
Drosophila melanogaster
Description:
ChEMBL_109136
Residue:
514
Sequence:
MKTLLVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFVLKRSTWRLLQESIRGEGEEVNNSEEEISLENTTTRNVLL
  
Inhibitor
Name:
BDBM50482586
Synonyms:
CHEMBL2374459
Type:
Small organic molecule
Emp. Form.:
C129H214N36O37S3
Mol. Mass.:
2957.493
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(O)=O |r|
Structure:
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