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Target
Alpha-1,2-mannosidase, putative
Ligand
BDBM50168995
Substrate
n/a
Meas. Tech.
ChEMBL_662786 (CHEMBL1252525)
Ki
5000±n/a nM
Citation
 Zhu, Y; Suits, MD; Thompson, AJ; Chavan, S; Dinev, Z; Dumon, C; Smith, N; Moremen, KW; Xiang, Y; Siriwardena, A; Williams, SJ; Gilbert, HJ; Davies, GJ Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont. Nat Chem Biol 6:125-32 (2010) [PubMed]  Article 
Target
Name:
Alpha-1,2-mannosidase, putative
Synonyms:
Alpha-1,2-mannosidase, putative
Type:
PROTEIN
Mol. Mass.:
87740.67
Organism:
Bacteroides thetaiotaomicron
Description:
ChEMBL_117209
Residue:
782
Sequence:
MYKASANILIACSFLWLTACSSAGVVTEDLIPTDYVNPFIGASTSVGAAGVYHGLGKTFPGATTPYGMVQVSPNTITGGDNSSGYSDEHKTIEGFAFTQMSGVGWFGDLGNFLVMPTTGELQKIAGKEDGSIKGYRSSYDKATETAKAGYYSVELTDYKIKVESSATPHCGILQFTFPSNEQSRIQIDLARRVGGTSTSQYVKVLDDYTIQGWMKCTPDGGGWGNGEGNSDYTVYYYAQFSKPLSNYGFWSADIPDEWVRKRDEVVSIPYLTRISQAPVIKDKKELEGKHLGFFTEFPTKEGEQVEMKVGISFVDMEGAANNFKQEIASKNFAQVKQEASDLWNKELSRIRISGGTDDEKTVFYTSLYHTMIDPRIYTDVDGRYIGGDKKVHEQDGTFTKRTIFSGWDVFRSQFPLQAMINPRLVSDALNSLITMADQSRREYYERWELLNSYSGCMIGNPALSVLADAYMKGIRTYDVEKAYQYAVNTSAKFGNDSLGYTPEPLSISYTLEYAYADWCVAQLAKALGKEEDAKRFYEKGQAYRNMFDAEKGWFRPRNADGSWKAWPENALTEEWYGCIESNAYQQGWFVPHDVPGMVELMGGKEEVIANLTNLFDHTPSDMLWNDYYNHANEPVHFVPFLFNQLDVPWYTQKWTRYICKNAYANKVEGIVGNEDVGQMSAWYILAASGIHPSCPGNTRMEITSPVFDKVEFNLDSKYHQGKVFTIIAHNNNTNNLYIQKALLNGKEYNKCYLDFAEIAAGGTLELFMGDKPNTEWGVLSNI
  
Inhibitor
Name:
BDBM50168995
Synonyms:
(-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indolizine-1,2,8-triol | 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL | CHEMBL371197 | SWAINSONINE
Type:
Small organic molecule
Emp. Form.:
C8H15NO3
Mol. Mass.:
173.2096
SMILES:
O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: