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Target
Reverse transcriptase
Ligand
BDBM33410
Substrate
n/a
Meas. Tech.
ChEMBL_675614 (CHEMBL1273922)
IC50
860±n/a nM
Citation
 Williams, PD; Staas, DD; Venkatraman, S; Loughran, HM; Ruzek, RD; Booth, TM; Lyle, TA; Wai, JS; Vacca, JP; Feuston, BP; Ecto, LT; Flynn, JA; DiStefano, DJ; Hazuda, DJ; Bahnck, CM; Himmelberger, AL; Dornadula, G; Hrin, RC; Stillmock, KA; Witmer, MV; Miller, MD; Grobler, JA Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold. Bioorg Med Chem Lett 20:6754-7 (2010) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM33410
Synonyms:
CHEMBL16755 | N-hydroxyisoquinolinedione, 2
Type:
Small organic molecule
Emp. Form.:
C9H7NO3
Mol. Mass.:
177.1568
SMILES:
ON1C(=O)Cc2ccccc2C1=O
Structure:
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