Reaction Details Report a problem with these data
Target
Bifunctional protein GlmU
Ligand
BDBM50483326
Substrate
n/a
Meas. Tech.
ChEMBL_708879 (CHEMBL1664948)
Ki
404±n/a nM
Citation
 Pereira, MP; Blanchard, JE; Murphy, C; Roderick, SL; Brown, ED High-throughput screening identifies novel inhibitors of the acetyltransferase activity of Escherichia coli GlmU. Antimicrob Agents Chemother 53:2306-11 (2009) [PubMed]  Article 
Target
Name:
Bifunctional protein GlmU
Synonyms:
Bifunctional protein (GlmU) | GLMU_ECOLI | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU | yieA
Type:
Enzyme
Mol. Mass.:
49189.50
Organism:
Escherichia coli
Description:
P0ACC7
Residue:
456
Sequence:
MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
  
Inhibitor
Name:
BDBM50483326
Synonyms:
CHEMBL1652296 | Mac0008028
Type:
Small organic molecule
Emp. Form.:
C36H24Cl4N2O8S4
Mol. Mass.:
882.656
SMILES:
Clc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1Cl)S(=O)(=O)c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: