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Target
Putative penicillin-binding protein 2B
Ligand
BDBM50483327
Substrate
n/a
Meas. Tech.
ChEMBL_708519 (CHEMBL1666333)
IC50
144±n/a nM
Citation
 Llarrull, LI; Fisher, JF; Mobashery, S Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. Antimicrob Agents Chemother 53:4051-63 (2009) [PubMed]  Article 
Target
Name:
Putative penicillin-binding protein 2B
Synonyms:
B9Z04_05970 | B9Z08_04335 | Cell division protein FtsI (Peptidoglycan synthetase) | EP54_05770 | EQ90_05620 | ERS072738_01739 | HMPREF3211_00860 | Penicillin-binding protein | Penicillin-binding protein 1 | Putative penicillin-binding protein 2B | Synonyms=ftsI_2 | pbp1 | pbpA
Type:
PROTEIN
Mol. Mass.:
82733.22
Organism:
Staphylococcus aureus
Description:
ChEMBL_105733
Residue:
744
Sequence:
MAKQKIKIKKNKIGAVLLVGLFGLLFFILVLRISYIMITGHSNGQDLVMKANEKYLVKNAQQPERGKIYDRNGKVLAEDVERYKLVAVIDKKASANSKKPRHVVDKKETAKKLSTVINMKPEEIEKRLSQKKAFQIEFGRKGTNLTYQDKLKIEKMNLPGISLLPETERFYPNGNFASHLIGRAQKNPDTGELKGALGVEKIFDSYLSGSKGSLRYIHDIWGYIAPNTKKEKQPKRGDDVHLTIDSNIQVFVEEALDGMVERYQPKDLFAVVMDAKTGEILAYSQRPTFNPETGKDFGKKWANDLYQNTYEPGSTFKSYGLAAAIQEGAFDPDKKYKSGHRDIMGSRISDWNRVGWGEIPMSLGFTYSSNTLMMHLQDLVGADKMKSWYERFGFGKSTKGMFDGEAPGQIGWSNELQQKTSSFGQSTTVTPVQMLQAQSAFFNDGNMLKPWFVNSVENPVSKRQFYKGQKQIAGKPITKDTAEKVEKQLDLVVNSKKSHAANYRIDGYEVEGKTGTAQVAAPNGGGYVKGPNPYFVSFMGDAPKKNPKVIVYAGMSLAQKNDQEAYELGVSKAFKPIMENTLKYLNVGKSKDDTSNAEYSKVPDVEGQDKQKAIDNVSAKSLEPVTIGSGTQIKAQSIKAGNKVLPHSKVLLLTDGDLTMPDMSGWTKEDVIAFENLTNIKVNLKGSGFVSHQSISKGQKLTEKDKIDVEFSSENVDSNSTNNSDSNSDDKKKSDSKTDKDKSD
  
Inhibitor
Name:
BDBM50483327
Synonyms:
CEFTOBIPROLE MEDOCARIL
Type:
Small organic molecule
Emp. Form.:
C26H26N8O11S2
Mol. Mass.:
690.662
SMILES:
[H][C@]12SCC(\C=C3/CCN([C@@H]4CCN(C4)C(=O)OCc4oc(=O)oc4C)C3=O)=C(N1C(=O)[C@H]2NC(=O)C(=N\O)\c1nsc(N)n1)C(O)=O |r,c:30|
Structure:
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