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Target
Reverse transcriptase
Ligand
BDBM50226664
Substrate
n/a
Meas. Tech.
ChEMBL_740498 (CHEMBL1764653)
IC50
171000±n/a nM
Citation
 Bodiwala, HS; Sabde, S; Mitra, D; Bhutani, KK; Singh, IP Synthesis of 9-substituted derivatives of berberine as anti-HIV agents. Eur J Med Chem 46:1045-9 (2011) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50226664
Synonyms:
2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium | CHEMBL400345 | columbamine
Type:
Small organic molecule
Emp. Form.:
C20H20NO4
Mol. Mass.:
338.3766
SMILES:
COc1cc2CC[n+]3cc4c(OC)c(OC)ccc4cc3-c2cc1O
Structure:
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